NDA Human body systems previous year questions with solutions
Human body systems is the second Biology chapter of the General Studies paper, about one question in forty-five, one to three a sitting, and respiration has climbed since 2025. Almost every question is one fact: an enzyme, a valve, a volume, a gland. Every question UPSC has set on it since 2017, solved. Grouped by the method each needs, newest first; open a question for its answer and worked solution.
16.1 Digestion: the alimentary canal, its glands and enzymes
Answer and solution
Answer: (c) Sphincter muscle
Method. Pyloric sphincter
The exit of food from the stomach is regulated by a sphincter muscle which releases it into the small intestine in small amounts (C5-A37).
Answer and solution
Answer: (a) pH 2.0 and 7.9, respectively
Method. Optimum pH of pepsin and trypsin
Pepsin acts in the acidic medium of the stomach at about pH 2 (C5-A35); trypsin of the pancreatic juice acts in the alkaline small intestine at about pH 8 (C5-A39, C5-A40, C5-A42). Only (a) has acid for pepsin and alkaline for trypsin; (d) wrongly gives a neutral pH for pepsin.
Answer and solution
Answer: (c) Secretion of lipase, amylase and protease
Method. Pancreatic enzymes
The pancreas secretes pancreatic juice with lipase, amylase and protease (trypsin) (C5-A42). Breaking up lipid droplets is by bile salts from the liver, bile is stored in the gall bladder, and neutralising acid is by bile (C5-A40).
Answer and solution
Answer: (b) bile and lipase
Method. Fat digestion by bile and lipase
Bile salts emulsify large fat globules into smaller ones, and lipase of the pancreatic juice then breaks down the emulsified fat (C5-A40, C5-A41, C5-A42). Trypsin and pepsin digest proteins and amylase digests starch.
Answer and solution
Answer: (c) pepsin
Method. Pepsin is the gastric protease
The gastric glands of the stomach wall release pepsin, a protein-digesting enzyme (C5-A34). Trypsin is secreted by the pancreas (C5-A42), amylase digests starch and chitinase digests chitin.
Answer and solution
Answer: (d) bile juice
Method. Bile makes the chyme alkaline
Bile juice from the liver makes the acidic food coming from the stomach alkaline so the pancreatic enzymes can act (C5-A40). This is the NCERT wording of the stem. Pancreatic juice is also alkaline and the nearest wrong option, but the Class 10 text names bile for this role; the option set has one answer in that reading.
Answer and solution
Answer: (a) Protein only
Method. Gastric acid activates pepsin
The acid-secreting (parietal) cells make HCl, which gives the acidic medium pepsin needs (C5-A34, C5-A35); without it protein digestion in the stomach fails. Carbohydrate digestion in the stomach is negligible (salivary amylase is stopped by acid), so carbohydrates are not affected in the same way; so (a), not (d).
16.2 Respiration: breathing, the lungs and cellular respiration
I. Glucose breaks down into pyruvate in the cytoplasm of all cells in both aerobic and anaerobic conditions.
II. The energy released during anaerobic respiration is greater than the energy released in aerobic respiration.
III. Carbon dioxide is released only in aerobic respiration.
Which of the statements given above is/are correct?
Answer and solution
Answer: (c) I and III
Method. statement analysis of animal respiration
I is true: glycolysis is cytoplasmic in all cells, aerobic or not (C5-A48). II is false: aerobic gives far more energy (C5-A52). III is true for animals: their anaerobic path ends in lactic acid (C5-A53), so CO2 comes only from aerobic respiration. The CO2 of fermentation (C5-A50) is yeast, not animals. Hence I and III.
Statement III is true only because the stem restricts to animals; yeast fermentation releases CO2 anaerobically.
I. The epithelial lining of alveoli is very thin.
II. Elastic fibres are present in alveolar wall.
III. Wall of alveoli is surrounded by many blood capillaries.
Select the correct answer using the code given below.
Answer and solution
Answer: (d) I, II and III
Method. Adaptations of the alveoli
The alveoli are the surface for gas exchange, with an extensive net of blood capillaries around them (C5-A63) and a very thin epithelium for fast diffusion; the elastic fibres of the wall let them expand and recoil with each breath. All three help, so (d). Elastic fibres help ventilation rather than diffusion.
Answer and solution
Answer: (b) Bronchi of humans
Method. Gas exchange sites
Gas exchange occurs in the skin of earthworms, the gills of Pila and the alveoli of humans (C5-A63). The bronchi are only air passages that lead to the alveoli (C5-A117). Negative stem.
Answer and solution
Answer: (b) Tidal volume
Method. Lung volumes compared
Typical values: tidal volume about 500 mL, expiratory reserve about 1000-1100 mL, residual about 1100-1200 mL, inspiratory reserve about 2500-3000 mL (C5-A65 for the residual volume). The tidal volume is the lowest. Standard result, Class 11 Biology.
Answer and solution
Answer: (b) Tidal volume
Method. Tidal volume
The volume of air breathed in or out in a normal breath, about 500 mL, is the tidal volume. Vital capacity is the maximum breathed out after a maximum breathing in. Standard result, Class 11 Biology (lung volumes and capacities); no row in the Class 10 set.
Answer and solution
Answer: (b) Bowman’s capsule
Method. Parts of the respiratory tract
Trachea and bronchi are air passages and the diaphragm drives inhalation (C5-A64, C5-A117). Bowman's capsule is part of the nephron of the kidney (C5-A101), so it takes no part in breathing. Negative stem: the answer is the part that does NOT help.
16.3 Circulation: blood, the heart and lymph
Answer and solution
Answer: (b) Semilunar valve
Method. Semilunar valves
The pulmonary valve at the opening of the right ventricle into the pulmonary artery is a semilunar valve (C5-A74, C5-A76). The tricuspid valve is between the right atrium and ventricle; the bicuspid or mitral valve is between the left atrium and ventricle. Standard result, Class 11 Biology.
Answer and solution
Answer: (b) Pulmonary arteries always carry oxygenated blood while Pulmonary veins always carry deoxygenated blood
Method. Arteries and veins; find the false statement
Statement (b) is reversed: the pulmonary artery carries deoxygenated blood to the lungs and the pulmonary veins carry oxygenated blood back to the left atrium (C5-A73, C5-A74, C5-A116). (a), (c) and (d) are true (C5-A82). Negative stem.
Answer and solution
Answer: (b) Fibrinogen
Method. Fibrinogen forms fibrin in clotting
Fibrinogen is the soluble plasma clotting protein that is converted into insoluble fibrin threads; platelets help to clot blood at the injury (C5-A84). A pathogen is a germ, macrophages and phagocytes are white blood cells. Standard result, Class 11 Biology (body fluids).
Answer and solution
Answer: (d) plasma
Method. Lymph resembles plasma
Lymph or tissue fluid is similar to plasma but colourless and with fewer proteins (C5-A85).
Answer and solution
Answer: (d) Electrocardiogram is graphical representation of electrical activity of heart
Method. ECG records the heart
An electrocardiogram records the electrical activity of the heart. The brain is recorded by an EEG. Standard result, Class 11 Biology (circulation).
Answer and solution
Answer: (a) left auricle
Method. Path of blood through the heart
Oxygen-rich blood from the lungs enters the left atrium (auricle) through the pulmonary veins (C5-A73); the right auricle receives deoxygenated blood from the body (C5-A74).
Answer and solution
Answer: (a) no nucleus, no mitochondria and no endoplasmic reticulum
Method. Structure of the mammalian red blood cell
Mature human RBCs lose the nucleus, mitochondria and endoplasmic reticulum, leaving room for haemoglobin; they get energy by glycolysis alone. Only (a) says all three are absent. Standard result (Class 11 Biology); no NCERT row for it in the Class 10 set.
16.4 Excretion: the kidney and the nephron
Answer and solution
Answer: (d) Bowman’s capsule
Method. Bowman's capsule filters
The basic filtration unit is the nephron: the glomerulus within the cup-shaped Bowman's capsule filters the blood (C5-A101). The collecting duct receives the filtrate from the tubule, the ureter carries urine (C5-A104) and the renal vein carries blood away.
Answer and solution
Answer: (a) Renin
Method. Renin-angiotensin system
Juxtaglomerular cells of the kidney secrete the enzyme renin, which converts the plasma protein angiotensinogen into angiotensin I; nitrogenase is a bacterial enzyme of nitrogen fixation, hydrolase and mono-oxygenase are enzyme classes, not this enzyme. Standard result (Class 11 Biology); no NCERT row for it in the Class 10 set.
16.5 Nervous system: neuron, reflex arc, brain and the sense organs
Answer and solution
Answer: (c) Corpus callosum
Method. Parts of the hind-brain
The hind-brain consists of the pons, the medulla and the cerebellum (C6-A17, C6-A64). The corpus callosum is a band of nerve fibres joining the two cerebral hemispheres of the fore-brain. Negative stem.
Answer and solution
Answer: (a) Involuntary actions such as blood pressure, salivation vomiting etc.
Method. Medulla of the hind-brain
Involuntary actions such as blood pressure, salivation and vomiting are controlled by the medulla in the hind-brain (C6-A22). Sensory regions and the hunger centre belong to the fore-brain (C6-A18, C6-A20). Option (c) is the nearest wrong one: voluntary movements are decided in the fore-brain, and the cerebellum only makes them precise (C6-A23).
Answer and solution
Answer: (d) sodium and potassium
Method. Na+ and K+ carry the impulse
The impulse in a nerve cell is carried by movement of Na+ and K+ ions across the membrane (Class 11 Biology, neural control). Keyed by the options: sodium alone and potassium alone are each only half the mechanism; iron plays no part. So (d).
Answer and solution
Answer: (b) cochlea
Method. Cochlea transduces sound
The cochlea of the inner ear converts the pressure variations of sound into electrical (nerve) signals; the auditory nerve only carries them to the brain, the eardrum vibrates and the eustachian tube equalises pressure. Standard result, Class 11 Biology (neural control, the ear).
Answer and solution
Answer: (d) is composed of proteins and cells.
Method. Structure of the cornea
The cornea is a transparent layer of cells and protein (collagen) with no blood vessels. The light sensitive screen is the retina and the muscular diaphragm is the iris, so (a), (b) and (c) are wrong. Standard result, Class 10 Science, human eye.
Answer and solution
Answer: (b) cornea
Method. Light enters through the cornea
Light enters the eye through the transparent cornea; the pupil is the opening in the iris and the retina is the screen at the back. Standard result, Class 10 Science, human eye; no assertion row for it in the Class 10 set listed.
Answer and solution
Answer: (c) retina
Method. Image forms on the retina
The retina is the light-sensitive screen at the back of the eye on which the image forms; the cornea and the lens refract the light, the iris controls the pupil. Standard result, Class 10 Science, human eye.
Answer and solution
Answer: (b) Receptor—sensory neuron—spinal cord—motor neuron—effector
Method. Order of a reflex arc
Receptor, sensory neuron, spinal cord, motor neuron, effector (C6-A11, C6-A12, C6-A63). Option (c) routes through the brain, which a reflex arc bypasses, since it is formed in the spinal cord.
Answer and solution
Answer: (b) Sodium
Method. Sodium ions carry the nerve impulse
The nerve impulse is carried by movement of Na+ (and K+) across the neuron membrane (Class 11 Biology, neural control). Of the elements offered only sodium is a biological ion; lithium, rubidium and caesium play no part in nerve conduction. Keyed by the options: sodium is the only one present among them.
Answer and solution
Answer: (a) Ultraviolet radiation
Method. Melanin absorbs ultraviolet
Melanin in skin, hair and iris absorbs ultraviolet radiation and so protects the DNA of skin cells from damage. Standard result, Class 11 Biology.
Answer and solution
Answer: (b) Cones
Method. Cones give colour vision
Cones, concentrated at the fovea, respond to bright light and distinguish colours; rods work in dim light. The blind spot and fovea are regions of the retina, not photoreceptor cell types. Standard result, Class 11 Biology (sense organs: the eye).
16.6 Endocrine glands and reproduction
Answer and solution
Answer: (b) Monkeys
Method. Oestrus cycle versus menstrual cycle
Cows, rats and tigers show an oestrus cycle (female receptive only at heat), but primates such as monkeys have the menstrual cycle. Negative stem. Standard result, Class 11 Biology.
Answer and solution
Answer: (b) Primary spermatocyte
Method. Meiosis I in spermatogenesis
The primary spermatocyte (2n) undergoes the first meiotic division, forming two secondary spermatocytes (n), which divide in meiosis II into spermatids. The spermatogonium divides by mitosis; the Sertoli cell is a supporting cell. Standard result, Class 11 Biology.
Answer and solution
Answer: (c) Ovary and pituitary gland
Method. Menstrual cycle hormones
The menstrual cycle is regulated by ovarian hormones (oestrogen and progesterone) under the control of the pituitary hormones (FSH and LH). Standard result, Class 11 Biology (reproductive health); the Class 10 set gives only the cycle itself (C7-A67, C7-A71).
Answer and solution
Answer: (d) Adrenaline
Method. Adrenaline speeds the heart
Adrenaline is secreted from the adrenal glands into the blood and makes the heart beat faster (C6-A47, C6-A48). Insulin regulates blood sugar and melatonin the sleep rhythm; thyroxine raises metabolic rate, not as the direct emergency heart hormone.
Answer and solution
Answer: (d) They inhibit the release of egg.
Method. Oral pills stop ovulation
Oral contraceptives change the hormonal balance so that eggs are not released and fertilisation cannot occur (C7-A76). They do not kill the egg, sperm or zygote.
Answer and solution
Answer: (b) Estrogen
Method. Oestrogen in females
At puberty oestrogen brings about the changes in appearance in females (C6-A53). Prolactin acts on milk production, oxytocin on birth and milk ejection, progesterone prepares and maintains the uterine lining. Standard result.
Answer and solution
Answer: (a) Cervix
Method. Male reproductive parts
The urethra, seminal vesicle and vas deferens belong to the male system; the cervix is the neck of the uterus in the female (C7-A64). Negative stem.
Answer and solution
Answer: (c) controls metabolic rate.
Method. Thyroxine controls metabolic rate
Thyroxine from the thyroid regulates the metabolic rate of the body. Blood glucose is controlled by insulin (C6-A54), ovulation and pregnancy by ovarian and pituitary hormones. Standard result, Class 11 Biology (endocrine system).
16.7 Skeleton, cartilage, teeth and tendons
Answer and solution
Answer: (c) Bronchiole
Method. Cartilage in the respiratory tract
The nose, the trachea (C-shaped rings) and the knee joint (articular cartilage, menisci) contain cartilage; the bronchioles are narrow tubes of smooth muscle without cartilage. Negative stem. Standard result, Class 11 Biology.
Answer and solution
Answer: (d) urinary bladder
Method. Where cartilage occurs
Cartilage supports the larynx, nose and external ear. The wall of the urinary bladder is smooth muscle with no cartilage (C5-A104). Negative stem. Standard result, Class 11 Biology (connective tissue).
Answer and solution
Answer: (d) Calcium phosphate
Method. Enamel is calcium phosphate
Tooth enamel is hydroxyapatite, a form of calcium phosphate, the hardest substance in the body. Standard result, Class 11 Biology; C5-A47 shows enamel is softened and demineralised by acid.
Answer and solution
Answer: (b) Collagen
Method. Tendon is made of collagen
Tendons are dense bundles of collagen, a tough fibrous protein; elastin is the stretchy protein of ligaments and arteries, fibrin forms blood clots, cellulose is a plant carbohydrate, not a protein. Standard result, Class 11 Biology (connective tissue).
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