NDA General Studies · Biology · 45 questions · 2017 to 2026

NDA Human body systems previous year questions with solutions

Human body systems is the second Biology chapter of the General Studies paper, about one question in forty-five, one to three a sitting, and respiration has climbed since 2025. Almost every question is one fact: an enzyme, a valve, a volume, a gland. Every question UPSC has set on it since 2017, solved. Grouped by the method each needs, newest first; open a question for its answer and worked solution.

16.1 Digestion: the alimentary canal, its glands and enzymes (7)16.2 Respiration: breathing, the lungs and cellular respiration (6)16.3 Circulation: blood, the heart and lymph (7)16.4 Excretion: the kidney and the nephron (2)16.5 Nervous system: neuron, reflex arc, brain and the sense organs (11)16.6 Endocrine glands and reproduction (8)16.7 Skeleton, cartilage, teeth and tendons (4)

16.1 Digestion: the alimentary canal, its glands and enzymes

1. NDA 2026 (II)
In humans, the exit of partially digested food from the stomach into the small intestine is regulated by which one of the following structures/⁠processes?
Answer and solution

Answer: (c) Sphincter muscle

Method. Pyloric sphincter

The exit of food from the stomach is regulated by a sphincter muscle which releases it into the small intestine in small amounts (C5-A37).

2. NDA 2025 (II)
The optimum pH at which the enzymes pepsin and trypsin of the human alimentary canal works are
Answer and solution

Answer: (a) pH 2.0 and 7.9, respectively

Method. Optimum pH of pepsin and trypsin

Pepsin acts in the acidic medium of the stomach at about pH 2 (C5-A35); trypsin of the pancreatic juice acts in the alkaline small intestine at about pH 8 (C5-A39, C5-A40, C5-A42). Only (a) has acid for pepsin and alkaline for trypsin; (d) wrongly gives a neutral pH for pepsin.

3. NDA 2024 (I)
In the human digestive system, which one among the following is the role of the pancreas?
Answer and solution

Answer: (c) Secretion of lipase, amylase and protease

Method. Pancreatic enzymes

The pancreas secretes pancreatic juice with lipase, amylase and protease (trypsin) (C5-A42). Breaking up lipid droplets is by bile salts from the liver, bile is stored in the gall bladder, and neutralising acid is by bile (C5-A40).

4. NDA 2022 (II)
The digestion of fat in human intestine is performed by
Answer and solution

Answer: (b) bile and lipase

Method. Fat digestion by bile and lipase

Bile salts emulsify large fat globules into smaller ones, and lipase of the pancreatic juice then breaks down the emulsified fat (C5-A40, C5-A41, C5-A42). Trypsin and pepsin digest proteins and amylase digests starch.

5. NDA 2022 (II)
The protein-digesting enzyme secreted by the stomach wall in case of mammals is called
Answer and solution

Answer: (c) pepsin

Method. Pepsin is the gastric protease

The gastric glands of the stomach wall release pepsin, a protein-digesting enzyme (C5-A34). Trypsin is secreted by the pancreas (C5-A42), amylase digests starch and chitinase digests chitin.

6. NDA 2018 (II)
The acidic semidigested food coming out of the stomach is neutralized by
Answer and solution

Answer: (d) bile juice

Method. Bile makes the chyme alkaline

Bile juice from the liver makes the acidic food coming from the stomach alkaline so the pancreatic enzymes can act (C5-A40). This is the NCERT wording of the stem. Pancreatic juice is also alkaline and the nearest wrong option, but the Class 10 text names bile for this role; the option set has one answer in that reading.

7. NDA 2018 (I)
If by an unknown accident the acid secreting cells of the stomach wall of an individual are damaged, digestion of which one of the following biomolecule will be affected to a greater extent?
Answer and solution

Answer: (a) Protein only

Method. Gastric acid activates pepsin

The acid-secreting (parietal) cells make HCl, which gives the acidic medium pepsin needs (C5-A34, C5-A35); without it protein digestion in the stomach fails. Carbohydrate digestion in the stomach is negligible (salivary amylase is stopped by acid), so carbohydrates are not affected in the same way; so (a), not (d).

16.2 Respiration: breathing, the lungs and cellular respiration

8. NDA 2026 (II)
Consider the following statements in relation to respiration in animals:
I. Glucose breaks down into pyruvate in the cytoplasm of all cells in both aerobic and anaerobic conditions.
II. The energy released during anaerobic respiration is greater than the energy released in aerobic respiration.
III. Carbon dioxide is released only in aerobic respiration.
Which of the statements given above is/⁠are correct?
Answer and solution

Answer: (c) I and III

Method. statement analysis of animal respiration

I is true: glycolysis is cytoplasmic in all cells, aerobic or not (C5-A48). II is false: aerobic gives far more energy (C5-A52). III is true for animals: their anaerobic path ends in lactic acid (C5-A53), so CO2 comes only from aerobic respiration. The CO2 of fermentation (C5-A50) is yeast, not animals. Hence I and III.

Statement III is true only because the stem restricts to animals; yeast fermentation releases CO2 anaerobically.

9. NDA 2026 (I)
Which of the following properties of alveoli is/⁠are helpful in gaseous exchange during respiration in human beings?
I. The epithelial lining of alveoli is very thin.
II. Elastic fibres are present in alveolar wall.
III. Wall of alveoli is surrounded by many blood capillaries.
Select the correct answer using the code given below.
Answer and solution

Answer: (d) I, II and III

Method. Adaptations of the alveoli

The alveoli are the surface for gas exchange, with an extensive net of blood capillaries around them (C5-A63) and a very thin epithelium for fast diffusion; the elastic fibres of the wall let them expand and recoil with each breath. All three help, so (d). Elastic fibres help ventilation rather than diffusion.

10. NDA 2026 (I)
In which of the following parts of organisms, the process of gaseous exchange during respiration does not take place?
Answer and solution

Answer: (b) Bronchi of humans

Method. Gas exchange sites

Gas exchange occurs in the skin of earthworms, the gills of Pila and the alveoli of humans (C5-A63). The bronchi are only air passages that lead to the alveoli (C5-A117). Negative stem.

11. NDA 2026 (I)
Which one of the following respiratory volumes of human lung is the lowest?
Answer and solution

Answer: (b) Tidal volume

Method. Lung volumes compared

Typical values: tidal volume about 500 mL, expiratory reserve about 1000-1100 mL, residual about 1100-1200 mL, inspiratory reserve about 2500-3000 mL (C5-A65 for the residual volume). The tidal volume is the lowest. Standard result, Class 11 Biology.

12. NDA 2025 (II)
The amount of air breathed in and out during a normal respiration by human lungs is referred to as
Answer and solution

Answer: (b) Tidal volume

Method. Tidal volume

The volume of air breathed in or out in a normal breath, about 500 mL, is the tidal volume. Vital capacity is the maximum breathed out after a maximum breathing in. Standard result, Class 11 Biology (lung volumes and capacities); no row in the Class 10 set.

13. NDA 2018 (I)
Which one of the following parts of body does NOT take part in the process of breathing?
Answer and solution

Answer: (b) Bowman’s capsule

Method. Parts of the respiratory tract

Trachea and bronchi are air passages and the diaphragm drives inhalation (C5-A64, C5-A117). Bowman's capsule is part of the nephron of the kidney (C5-A101), so it takes no part in breathing. Negative stem: the answer is the part that does NOT help.

16.3 Circulation: blood, the heart and lymph

14. NDA 2026 (I)
Which one of the following valves guards the opening between the right ventricle and the pulmonary artery?
Answer and solution

Answer: (b) Semilunar valve

Method. Semilunar valves

The pulmonary valve at the opening of the right ventricle into the pulmonary artery is a semilunar valve (C5-A74, C5-A76). The tricuspid valve is between the right atrium and ventricle; the bicuspid or mitral valve is between the left atrium and ventricle. Standard result, Class 11 Biology.

15. NDA 2025 (II)
Which one among the following statements about arteries and veins in humans is NOT correct?
Answer and solution

Answer: (b) Pulmonary arteries always carry oxygenated blood while Pulmonary veins always carry deoxygenated blood

Method. Arteries and veins; find the false statement

Statement (b) is reversed: the pulmonary artery carries deoxygenated blood to the lungs and the pulmonary veins carry oxygenated blood back to the left atrium (C5-A73, C5-A74, C5-A116). (a), (c) and (d) are true (C5-A82). Negative stem.

16. NDA 2025 (I)
Clotting of blood involves which one among the following clotting proteins?
Answer and solution

Answer: (b) Fibrinogen

Method. Fibrinogen forms fibrin in clotting

Fibrinogen is the soluble plasma clotting protein that is converted into insoluble fibrin threads; platelets help to clot blood at the injury (C5-A84). A pathogen is a germ, macrophages and phagocytes are white blood cells. Standard result, Class 11 Biology (body fluids).

17. NDA 2022 (II)
Lymph is a tissue fluid present in intercellular spaces. It resembles to
Answer and solution

Answer: (d) plasma

Method. Lymph resembles plasma

Lymph or tissue fluid is similar to plasma but colourless and with fewer proteins (C5-A85).

18. NDA 2019 (I)
Which one of the following statements regarding Electrocardiogram is correct?
Answer and solution

Answer: (d) Electrocardiogram is graphical representation of electrical activity of heart

Method. ECG records the heart

An electrocardiogram records the electrical activity of the heart. The brain is recorded by an EEG. Standard result, Class 11 Biology (circulation).

19. NDA 2018 (II)
The oxygenated blood from the lungs is received by the
Answer and solution

Answer: (a) left auricle

Method. Path of blood through the heart

Oxygen-rich blood from the lungs enters the left atrium (auricle) through the pulmonary veins (C5-A73); the right auricle receives deoxygenated blood from the body (C5-A74).

20. NDA 2017 (I)
Red blood cells (RBCs) have
Answer and solution

Answer: (a) no nucleus, no mitochondria and no endoplasmic reticulum

Method. Structure of the mammalian red blood cell

Mature human RBCs lose the nucleus, mitochondria and endoplasmic reticulum, leaving room for haemoglobin; they get energy by glycolysis alone. Only (a) says all three are absent. Standard result (Class 11 Biology); no NCERT row for it in the Class 10 set.

16.4 Excretion: the kidney and the nephron

21. NDA 2024 (II)
Which part of nephron of the human kidney is responsible for filtration of blood for excretion?
Answer and solution

Answer: (d) Bowman’s capsule

Method. Bowman's capsule filters

The basic filtration unit is the nephron: the glomerulus within the cup-shaped Bowman's capsule filters the blood (C5-A101). The collecting duct receives the filtrate from the tubule, the ureter carries urine (C5-A104) and the renal vein carries blood away.

22. NDA 2017 (I)
Kidney secretes an enzyme, which changes plasma protein angiotensinogen into angiotensin. The enzyme is
Answer and solution

Answer: (a) Renin

Method. Renin-angiotensin system

Juxtaglomerular cells of the kidney secrete the enzyme renin, which converts the plasma protein angiotensinogen into angiotensin I; nitrogenase is a bacterial enzyme of nitrogen fixation, hydrolase and mono-oxygenase are enzyme classes, not this enzyme. Standard result (Class 11 Biology); no NCERT row for it in the Class 10 set.

16.5 Nervous system: neuron, reflex arc, brain and the sense organs

23. NDA 2026 (II)
Which one of the following is not a part of the hindbrain of human beings?
Answer and solution

Answer: (c) Corpus callosum

Method. Parts of the hind-brain

The hind-brain consists of the pons, the medulla and the cerebellum (C6-A17, C6-A64). The corpus callosum is a band of nerve fibres joining the two cerebral hemispheres of the fore-brain. Negative stem.

24. NDA 2025 (II)
Identify the functions that are controlled by the hind brain of human being
Answer and solution

Answer: (a) Involuntary actions such as blood pressure, salivation vomiting etc.

Method. Medulla of the hind-brain

Involuntary actions such as blood pressure, salivation and vomiting are controlled by the medulla in the hind-brain (C6-A22). Sensory regions and the hunger centre belong to the fore-brain (C6-A18, C6-A20). Option (c) is the nearest wrong one: voluntary movements are decided in the fore-brain, and the cerebellum only makes them precise (C6-A23).

25. NDA 2022 (II)
The transfer of electrical signals by nerve cells in human body is enabled by
Answer and solution

Answer: (d) sodium and potassium

Method. Na+ and K+ carry the impulse

The impulse in a nerve cell is carried by movement of Na+ and K+ ions across the membrane (Class 11 Biology, neural control). Keyed by the options: sodium alone and potassium alone are each only half the mechanism; iron plays no part. So (d).

26. NDA 2022 (II)
The part of the human ear that converts the pressure variations associated with audible sound waves to electrical signals is
Answer and solution

Answer: (b) cochlea

Method. Cochlea transduces sound

The cochlea of the inner ear converts the pressure variations of sound into electrical (nerve) signals; the auditory nerve only carries them to the brain, the eardrum vibrates and the eustachian tube equalises pressure. Standard result, Class 11 Biology (neural control, the ear).

27. NDA 2021 (II)
Cornea in human eye
Answer and solution

Answer: (d) is composed of proteins and cells.

Method. Structure of the cornea

The cornea is a transparent layer of cells and protein (collagen) with no blood vessels. The light sensitive screen is the retina and the muscular diaphragm is the iris, so (a), (b) and (c) are wrong. Standard result, Class 10 Science, human eye.

28. NDA 2020 (I)
Light enters the eye through a thin membrane called
Answer and solution

Answer: (b) cornea

Method. Light enters through the cornea

Light enters the eye through the transparent cornea; the pupil is the opening in the iris and the retina is the screen at the back. Standard result, Class 10 Science, human eye; no assertion row for it in the Class 10 set listed.

29. NDA 2020 (I)
The part of the human eye on which the image is formed is
Answer and solution

Answer: (c) retina

Method. Image forms on the retina

The retina is the light-sensitive screen at the back of the eye on which the image forms; the cornea and the lens refract the light, the iris controls the pupil. Standard result, Class 10 Science, human eye.

30. NDA 2018 (II)
Which one of the following depicts the correct circuit of a reflex arc?
Answer and solution

Answer: (b) Receptor—sensory neuron—spinal cord—motor neuron—effector

Method. Order of a reflex arc

Receptor, sensory neuron, spinal cord, motor neuron, effector (C6-A11, C6-A12, C6-A63). Option (c) routes through the brain, which a reflex arc bypasses, since it is formed in the spinal cord.

31. NDA 2018 (I)
Which one of the following elements is needed in the human body to transfer electrical signals by nerve cells?
Answer and solution

Answer: (b) Sodium

Method. Sodium ions carry the nerve impulse

The nerve impulse is carried by movement of Na+ (and K+) across the neuron membrane (Class 11 Biology, neural control). Of the elements offered only sodium is a biological ion; lithium, rubidium and caesium play no part in nerve conduction. Keyed by the options: sodium is the only one present among them.

32. NDA 2017 (II)
Melanin is the natural pigment that gives colour to human skin, hair and the iris. It provides protection against
Answer and solution

Answer: (a) Ultraviolet radiation

Method. Melanin absorbs ultraviolet

Melanin in skin, hair and iris absorbs ultraviolet radiation and so protects the DNA of skin cells from damage. Standard result, Class 11 Biology.

33. NDA 2017 (I)
Colour vision in human eyes is the function of photoreceptor cells named
Answer and solution

Answer: (b) Cones

Method. Cones give colour vision

Cones, concentrated at the fovea, respond to bright light and distinguish colours; rods work in dim light. The blind spot and fovea are regions of the retina, not photoreceptor cell types. Standard result, Class 11 Biology (sense organs: the eye).

16.6 Endocrine glands and reproduction

34. NDA 2026 (I)
In which one of the following groups of animals, oestrus cycle is not observed?
Answer and solution

Answer: (b) Monkeys

Method. Oestrus cycle versus menstrual cycle

Cows, rats and tigers show an oestrus cycle (female receptive only at heat), but primates such as monkeys have the menstrual cycle. Negative stem. Standard result, Class 11 Biology.

35. NDA 2026 (I)
In which cell does the first meiotic cell division take place during the process of spermatogenesis?
Answer and solution

Answer: (b) Primary spermatocyte

Method. Meiosis I in spermatogenesis

The primary spermatocyte (2n) undergoes the first meiotic division, forming two secondary spermatocytes (n), which divide in meiosis II into spermatids. The spermatogonium divides by mitosis; the Sertoli cell is a supporting cell. Standard result, Class 11 Biology.

36. NDA 2025 (II)
The menstrual cycle in females is controlled by hormones that are secreted by
Answer and solution

Answer: (c) Ovary and pituitary gland

Method. Menstrual cycle hormones

The menstrual cycle is regulated by ovarian hormones (oestrogen and progesterone) under the control of the pituitary hormones (FSH and LH). Standard result, Class 11 Biology (reproductive health); the Class 10 set gives only the cycle itself (C7-A67, C7-A71).

37. NDA 2022 (II)
Which one of the following hormones increases the heartbeat in mammals?
Answer and solution

Answer: (d) Adrenaline

Method. Adrenaline speeds the heart

Adrenaline is secreted from the adrenal glands into the blood and makes the heart beat faster (C6-A47, C6-A48). Insulin regulates blood sugar and melatonin the sleep rhythm; thyroxine raises metabolic rate, not as the direct emergency heart hormone.

38. NDA 2022 (I)
Which one of the following is the mechanism of action of oral contraceptive pills?
Answer and solution

Answer: (d) They inhibit the release of egg.

Method. Oral pills stop ovulation

Oral contraceptives change the hormonal balance so that eggs are not released and fertilisation cannot occur (C7-A76). They do not kill the egg, sperm or zygote.

39. NDA 2021 (II)
Which one of the following hormones is responsible for the development of female sexual characters?
Answer and solution

Answer: (b) Estrogen

Method. Oestrogen in females

At puberty oestrogen brings about the changes in appearance in females (C6-A53). Prolactin acts on milk production, oxytocin on birth and milk ejection, progesterone prepares and maintains the uterine lining. Standard result.

40. NDA 2020 (I)
Which one of the following is NOT a component of human male reproductive system?
Answer and solution

Answer: (a) Cervix

Method. Male reproductive parts

The urethra, seminal vesicle and vas deferens belong to the male system; the cervix is the neck of the uterus in the female (C7-A64). Negative stem.

41. NDA 2019 (II)
Thyroid gland produces a hormone called “Thyroxine” which
Answer and solution

Answer: (c) controls metabolic rate.

Method. Thyroxine controls metabolic rate

Thyroxine from the thyroid regulates the metabolic rate of the body. Blood glucose is controlled by insulin (C6-A54), ovulation and pregnancy by ovarian and pituitary hormones. Standard result, Class 11 Biology (endocrine system).

16.7 Skeleton, cartilage, teeth and tendons

42. NDA 2024 (II)
In which part or organ of human body cartilage is NOT found?
Answer and solution

Answer: (c) Bronchiole

Method. Cartilage in the respiratory tract

The nose, the trachea (C-shaped rings) and the knee joint (articular cartilage, menisci) contain cartilage; the bronchioles are narrow tubes of smooth muscle without cartilage. Negative stem. Standard result, Class 11 Biology.

43. NDA 2020 (I)
Cartilage is NOT found in
Answer and solution

Answer: (d) urinary bladder

Method. Where cartilage occurs

Cartilage supports the larynx, nose and external ear. The wall of the urinary bladder is smooth muscle with no cartilage (C5-A104). Negative stem. Standard result, Class 11 Biology (connective tissue).

44. NDA 2019 (I)
Tooth enamel is made up of which one of the following calcium compounds?
Answer and solution

Answer: (d) Calcium phosphate

Method. Enamel is calcium phosphate

Tooth enamel is hydroxyapatite, a form of calcium phosphate, the hardest substance in the body. Standard result, Class 11 Biology; C5-A47 shows enamel is softened and demineralised by acid.

45. NDA 2017 (II)
Tendons through which muscles are connected to bones are tightly compacted bundles of which one of the following long fibrous protein?
Answer and solution

Answer: (b) Collagen

Method. Tendon is made of collagen

Tendons are dense bundles of collagen, a tough fibrous protein; elastin is the stretchy protein of ligaments and arteries, fibrin forms blood clots, cellulose is a plant carbohydrate, not a protein. Standard result, Class 11 Biology (connective tissue).

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